Current campus guidelines for any gathering other than academic classes, professional education programs (GTPE), or department meetings are available at

Thursday, February 11 2021
4:00pm - 5:00pm
Event hosted virtually at
For more information:

Bluejeans link for the seminar is available here.

Contact Daniel Muratore (here) for questions. 

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QBioS Student Seminar Series - Guanlin Li

Optimizing use of multiphage ‘cocktails’ for treatment of immunodeficient hosts: a model-based control approach

The addition of therapeutic phage to treat Multi-Drug Resistant (MDR) pathogens imposes a strong selective pressure for the emergence of phage-resistant bacteria. Modeling and in vivo experiments have established that phage-resistant bacteria proliferate in Myd88-/- (immunodeficient) mice, corresponding to a failure of phage therapy. This work aims to develop evolutionarily robust phage therapy in immunodeficient hosts. First, we consider a model where bacteria evolve in an abstract discrete phenotypic space against different types of phages present in a therapeutic phage library. Second, we formulate a single-dose optimization problem subject to the proposed eco-evolutionary dynamics. The goal is to minimize the total bacterial population while penalizing the treatment costs by optimizing the phage therapy administrations. Finally, we extend single-dose treatment to multi-dose treatment and find the optimal policy via control theory. 

This seminar will be hosted at this bluejeans link.

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