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Thursday, March 26 2020
10:55am
Room 1005, Roger A. and Helen B. Krone Engineered Biosystems Building (EBB), 950 Atlantic Dr NW, Atlanta, GA 30332
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(Postponed) Molecular Mechanisms of Stem Cell and Developmental Potency

The Biological Sciences Seminar featuring Jianlong Wang, originally scheduled for March 26, 2020, has been postponed. Please visit biosci.gatech.edu for further updates.

Jianlong Wang, Ph.D.
Columbia Center for Human Development,
Columbia University Irving Medical Center

ABSTRACT
Molecular control of stem cell and developmental potencyresides in a core circuitry of master transcription factors that act in conjunction with epigenetic cofactors for activation and repression of downstream target genes. We have employedboth genomic and proteomic approaches as well as mouse models to study protein-protein interaction and protein-DNAregulatory networks that govern embryonic stem cell (ESC) pluripotency, somatic cell reprogramming, and embryogenesis. Our long-term goal isto understand how cell identity is established, maintained, and altered during mammalian (both mouse and human) developmentunder both normal and pathological conditions. In my talk, I will discussour published and unpublished work dissecting molecular mechanismsunderlying ESCpluripotency, somatic cell reprogramming, and totipotency-to-pluripotency transition during early development.

Host: Yuhong Fan