Thursday, September 12 2019
10:55am
Room 1005, Roger A. and Helen B. Krone Engineered Biosystems Building (EBB), 950 Atlantic Dr NW, Atlanta, GA 30332
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Evolution-Proof Drugs: Conditional Treatment Strategies for Effective and Evolutionarily Robust Infection Control

Sam Brown, Ph.D.
School of Biological Sciences
Georgia Institute of Technology

ABSTRACT
Infection medicine currently faces two major and growing crises that impact the ability of MDs to treat bacterial infections with our current arsenal of antibiotics. The first is widely recognised – the evolution of antibiotic resistance. The second receives less attention – chronic polymicrobial infections where appropriate antibiotics often fail to resolve infections. I will discuss novel patient-specific control strategies that have the potential to effectively treat patients now and into the future. These diagnostic-conditional strategies are grounded in multi-scale modeling and experimentation, from within-host dynamics of multi-species infection microbiomes through to the epidemiological and evolutionary dynamics of competing pathogen strains.

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